Abstract:

Objective To observe the clinical efficacy of intravitreal lucentis injection combined with Laser treatment in the treatment of multiple chronic central serous chorioretinopathy(CSC). Design Retrospective case series. Participants 20 eyes of 13 patients with multiple CSC were enrolled. Methods All patients were confirmed by best corrected visual acuity (BCVA), fundus fluorescein anglograph (FFA) and spectral domain optical coherence tomography (SD-OCT). All the patients were treated with an intravitreal injection of lucentis, 4 weeks after injection, laser treatment were performed. Patients had follow-up on 4,8,12 weeks after all the treatment. Main Outcome Measures included pre and post treatment changes in BCVA, FFA and subretinal fluid (SRF). Results 4 weeks after the lucentis injection, the nerve epithelium or pigment epithelium detachment was significantly improved in all eyes. All of the patients BCVA were significantly improved (from 0.47±0.24 to 0.70±0.16, P=0.042). The SRF was (445±134) μm before treatment, and it was (182±101) μm after intravitreal lucentis injection treatment 4 weeks. The SRF was (59±11) μm (P=0.004) after 8 weeks combined treatment. The SRF of parafoveal was (409±112) μm before treatment, after 4 weeks lucentis treatment it was (142±87) μm and the SRF was (50±15) μm after 8 weeks combined treatment. The FFA showed no abnormal leakage 12 weeks after all treated. Conclusion Intravitreal lucentis injection combined with laser treatment of multiple CSC has curative effect. Intravitreal lucentis injection treatment can work on leakage points, at the same time, promote the retinal neuroepithelium and pigment epithelium under liquid absorption, shorten the treatment time, improve patients' BCVA, and reduce the retinal damage by laser treatment.  (Ophthalmol CHN, 2016, 25: 59-62)

Key words:  multiplecentral serous chorioretinopathy, laser treatment, lucentis, anti-VEGF therapy